William Rosencrans

03 · Endoplasmic Reticulum

Publications

The rough ER is studded with ribosomes, translating and folding the cell’s output. Here’s what my team and I have been building.

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  1. Three mammalian VDAC isoforms distinctly regulate mitochondrial function and proteome to maintain cell metabolismCo-first author

    Rajendran M, Rosencrans WM, Bautista NA, Fitzgerald W, Huynh D, Beyene BG, Quan B, Petersen JD, Hwang J, Chou TF, Bezrukov SM, Rostovtseva TK

    Journal of Biological Chemistry 302(1), 111009 · 2026

  2. Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stressFirst authorPress

    Rosencrans WM, Lee RW, McGraw L, Horsburgh I, Wang TY, Quan B, Huynh D, Johnston JA, Chan DC, Chou TF

    Science Advances 11(35), eady0240 · 2025 · Caltech news

  3. Conformational plasticity of mitochondrial VDAC2 controls the kinetics of its interaction with cytosolic proteinsFirst author

    Rosencrans WM, Khuntia H, Ghahari Larimi M, Mahalakshmi R, Yu TY, Bezrukov SM, Rostovtseva TK

    Science Advances 11(17), eadv4410 · 2025

  4. Dimeric Tubulin Modifies Mechanical Properties of Lipid Bilayer, as Probed Using Gramicidin A Channel

    Rostovtseva TK, Weinrich M, Jacobs D, Rosencrans WM, Bezrukov SM

    International Journal of Molecular Sciences 25(4), 2204 · 2024

  5. Fusion activators enhance mitochondrial functionFirst authorCommentary

    Rosencrans WM, Chan DC

    Mitochondrial Communications 1, 33-34 · 2023

  6. TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

    Le Guerroué F, Bunker EN, Rosencrans WM, Nguyen JT, Basar MA, Werner A, Chou TF, Wang C, Youle RJ

    Molecular Cell 83(6), 927-941.e8 · 2023

  7. Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein-VDAC complexation as a potential therapeutic target for Parkinson's disease treatment

    Rajendran M, Queralt-Martín M, Gurnev PA, Rosencrans WM, Rovini A, Jacobs D, Abrantes K, Hoogerheide DP, Bezrukov SM, Rostovtseva TK

    Cellular and Molecular Life Sciences 79(7), 368 · 2022

  8. Sulforaphane is Synergistic with CB-5083 and Inhibits Colony Formation of CB-5083-Resistant HCT116 Cells

    Wang F, Li S, Rosencrans WM, Cheng KW, Stott GM, Mroczkowski B, Chou TF

    ChemMedChem 17(11), e202200030 · 2022

  9. The p97 Inhibitor UPCDC-30245 Blocks Endo-Lysosomal Degradation

    Wang F, Li S, Cheng KW, Rosencrans WM, Chou TF

    Pharmaceuticals 15(2), 204 · 2022

  10. α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transportFirst author

    Rosencrans WM, Aguilella VM, Rostovtseva TK, Bezrukov SM

    Cell Calcium 95, 102355 · 2021

  11. VDAC regulation of mitochondrial calcium flux: From channel biophysics to diseaseFirst authorReview

    Rosencrans WM, Rajendran M, Bezrukov SM, Rostovtseva TK

    Cell Calcium 94, 102356 · 2021

  12. Internal Motion of Chromatin Fibers Is Governed by Dynamics of Uncompressed Linker Strands

    Basak R, Rosencrans W, Yadav I, Yan P, Berezhnoy NV, Chen Q, van Kan JA, Nordenskiöld L, Zinchenko A, van der Maarel JRC

    Biophysical Journal 119(11), 2326-2334 · 2020

  13. Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic DrugsReview

    Rostovtseva TK, Queralt-Martín M, Rosencrans WM, Bezrukov SM

    Frontiers in Physiology 11, 446 · 2020

  14. Cells deficient for Krüppel-like factor 4 exhibit mitochondrial dysfunction and impaired mitophagyFirst author

    Rosencrans WM, Walsh ZH, Houerbi N, Blum A, Belew M, Liu C, Chernak B, Brauer PR, Trazo A, Olson A, Hagos E

    European Journal of Cell Biology 99(1), 151061 · 2020

  15. Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

    Rovini A, Gurnev PA, Beilina A, Queralt-Martín M, Rosencrans W, Cookson MR, Bezrukov SM, Rostovtseva TK

    Cellular and Molecular Life Sciences 77(18), 3611-3626 · 2020

  16. Intramolecular dynamics of dsDNA confined to a quasi-one-dimensional nanochannel

    Yadav I, Rosencrans W, Basak R, van Kan JA, van der Maarel JRC

    Physical Review Research 2(1), 013294 · 2020

  17. Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling

    Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS

    BBA – Molecular and Cell Biology of Lipids 1864(10), 1269-1279 · 2019

  18. Krüppel-like factor 4 mediates cellular migration and invasion by altering RhoA activity

    Brauer PR, Kim JH, Ochoa HJ, Stratton ER, Black KM, Rosencrans W, Stacey E, Hagos EG

    Cell Communication & Adhesion 24(1), 1-10 · 2018

  19. Single-molecule compaction of megabase-long chromatin molecules by multivalent cations

    Zinchenko A, Berezhnoy NV, Wang S, Rosencrans WM, Korolev N, van der Maarel JRC, Nordenskiöld L

    Nucleic Acids Research 46(2), 635-649 · 2018